Prodrug Strategy in Drug Development

development and implementation of an optimized control strategy for induction machine in an electric vehicle

in the area of automotive engineering there is a tendency to more electrification of power train. in this work control of an induction machine for the application of electric vehicle is investigated. through the changing operating point of the machine, adapting the rotor magnetization current seems to be useful to increase the machines efficiency. in the literature there are many approaches wh...

Prodrug Design vs. Drug Design

A drug is defined as a substance which is used in the cure, relief, diagnosis, treatment, or prevention of disease. The development of any potential drug commences with the study of the biochemistry and physiology behind a disease for which pharmaceutical intervention is feasible [1]. Prodrug is a term that was first introduced by Albert to signify a pharmacologically inactive chemical moiety t...

Prodrug approach in current drug discovery.

úDrugs need to be designed with delivery in mindû is what the late Professor Takeru Higuchi said to Professor V. J. Stella in the mid-1970s.1¥ This paradigm is very important in terms of drug discovery, and it should be borne in mind at all stages of drug development. DMPK research has helped to develop drugs with suitable pharmacokinetic properties. Novel formulation approaches also help overc...

Paclitaxel-2'-O-pentadecylhemiglutarate: A Prodrug Strategy for Albumin Based Drug Delivery

Prodrug strategy to achieve lyophilizable, high drug loading micelle formulations through diester derivatives of β-Lapachone.

β-Lap prodrug micelle strategy improves the formulation properties of β-lap therapeutics. The resulting micelles yield apparent high β-lap solubility (>7 mg mL(-1) ), physical stability, and ability to reconstitute after lyophilization. In the presence of esterase, β-lap prodrugs are efficiently converted into parent drug (i.e., β-lap), resulting in NQO1-dependent lethality of NSCLC cells.